Recurrent BCG Infection in a Boy With X-Linked Chronic Granulomatous Disease.
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منابع مشابه
DISSEMINATED INFECTION DUE TO FUSARIUM SP. IN A PATIENT WI TH CHRONIC GRANULOMATOUS DISEASE
The present report discusses disseminated fusariosis in a 15 year old boy with chronic granulomatous disease (CGD). He was admitted to the Hazrat Rasool Acram Hospital in November 1995, with a chronic wound in the right ankle and buttock area. Antibacterial therapy was started, but there was no response. The patient was still febrile. Chest x-ray revealed parahilar lesions in both lungs. Ti...
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Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by increased susceptibility to bacteria and fungi since early in life, caused by mutations in any of the five genes coding for protein subunits in NADPH oxidase. X-linked variant CGD can be missed during routine evaluation or present later in life due to hypomorphic mutations and a residual superoxide production. Th...
متن کاملA novel mutation of the CYBB gene resulting in severe form of X-linked chronic granulomatous disease.
We evaluated a boy who had multiple Salmonella septicemia, Aspergillus pneumonia and brain abscesses. His nitroblue tetrazolium (NBT) test was reportedly abnormal. The dihydrorhodamine (DHR) flow cytometry assay was compatible with typical X-linked chronic granulomatous disease (X-CGD). CYBB analysis revealed a novel complex mutation atggacg --> ttca in exon 12 (base pairs 1532-1538). As a resu...
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The attenuated strain of Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it occasionally leads to a benign regional adenitis. In rare cases, however, vaccination causes disseminated BCG infection, which may be lethal. Impaired immunity of the host is generally thought to be the...
متن کاملOsteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report: Herein, we present a case of fungal infection in a girl wi...
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عنوان ژورنال:
- Journal of investigational allergology & clinical immunology
دوره 25 5 شماره
صفحات -
تاریخ انتشار 2015